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Glibenclamide

Synonyms: LABOTEST-BB LT00244861;GLYBENCLAMIDE;GLYBENZCYCLAMIDE;GLYBURIDE;GIBENCLAMIDE;GLIBENCLAMIDE;5-CHLORO-N-[4-(CYCLOHEXYLUREIDOSULFONYL)PHENETHYL]-2-METHOXYBENZAMIDE;5-CHLORO-N-[2-[4-[[[(CYCLOHEXYLAMINO)CARBONYL]AMINO]-SULFONYL]PHENYL]ETHYL]-2-METHOXYBENZAMIDE

CAS: 10238-21-8

MF: C23H28ClN3O5S

MW: 494

EINECS: 233-570-6

Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organics;Amino Acids & Derivatis;Isotope Labeled Compounds;API's;Potassium channel;Ion Channels;Isotope Labelled Compounds;API;GLYNASE;Diabetes Research

Mol File: 10238-21-8.mol

Glibenclamide Structure

Glibenclamide Chemical Properties

Melting point 173-175°C

storage temp. 2-8°C

solubility ethanol: soluble2mg/mL

pka 5.3(at 25℃)

Water Solubility Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.

Merck 13,4491

InChIKey ZNNLBTZKUZBEKO-UHFFFAOYSA-N

CAS DataBase Reference 10238-21-8(CAS DataBase Reference)

NIST Chemistry Reference Glyburide(10238-21-8)

Glibenclamide Usage

Uses Hypoglycemic agents with stronger effect than toluene sulfonylurea; used for the treatment of mild, non-insulin-dependent diabetes;

Hazards & Safety Information Category : Toxic substances

Toxic classification:  poisoning

Acute toxicity:  Intraperitoneal-rat LD50: 3750 mg/kg; Oral-mouse LD50: 3250 mg/kg

Flammability Hazardous characteristics : Thermal decomposition releases toxic nitrogen oxides, sulfur oxides, chloride fumes

Storage and transport characteristics:  Treasury: low temperature, ventilated and dry

Extinguishing agent : water, carbon dioxide, foam, dry powder

Chemical Properties White Crystalline Powder

Uses antihyperglycemic

Uses Glyburide is a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic.

Uses An ATP-dependent KIR6 and CFTR Cl- channel blocker

Definition ChEBI: An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.

Biological Activity ATP-dependent K + channel (K ATP ) and CFTR Cl - channel blocker. Inhibits K ATP currents in the pancreas, causing an increase in intracellular Ca 2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC 50 of 20 μ M.